The San Diego IRACDA provides training directed at preparing post-docs to enter the professoriate: mentored research training, mentored lecturing to undergraduates; a course in organizational behavior and structure of universities and colleges, including interviewing and negotiating job contracts; grant writing; and a seminar series run by the post-docs.

IRACDA also provides travel funding to attend a national meeting each year and the annual IRACDA conference.

Questions? Read the FAQ.

To apply, please submit the following via email:

(1) A Personal Statement - this should outline your career, background, and history in science, including both experiences and future goals, particularly highlighting any interest in becoming a professor.

(2) A Curriculum Vitae

(3) Two Letters of Recommendation (one being from your doctoral mentor) submitted directly to Dr. Brunton via email.

[lbrunton@ucsd.edu]

 

 

Brunton, Laurence L.
Pozos, Robert S.


Brunton, Laurence L.
Pharmacology and Medicine

Education
Harvard College, Cambridge, MA: B.A. 1965-1969 Biochemical Sciences
University of Virginia, Charlottesville: Ph.D. 1971-1976 Pharmacology
University of California, San Diego: Postdoc 1976-1978 Pharmacology

Positions and Honors
1976-1978 NIH Postdoctoral Fellowship (HL 05363)
1978-1980 Univ. of California, San Diego, Lecturer in Medicine and Assistant Research Pharmacologist
1981-1986 Univ. of California, San Diego, Asst. Prof. of Medicine, Divisions of Cardiology and Pharmacology
1981-1986 Research Career Development Award (HL 00935)
1986-1997 Univ. of California, San Diego, Associate Professor of Pharmacology and Medicine (Cardiology)
1997-Pres. Univ. of California, San Diego, Professor of
Pharmacology and Medicine
1997-1999 Chairman, Biomedical Sciences Graduate Program

Selected peer-reviewed publications
(in chronological order, since 1996):
Villegas S and Brunton LL (1996) Cellular localization and characterization of cyclic GMP production in rat heart. Cardiovasc Pathobiol 1:5-12.

Villegas S and Brunton LL (1996) Separation of Cyclic GMP and Cyclic AMP. Analyt. Biochem, 235:102-103.

Brunton LL and Bloor CM (1996) Commentary: Transcriptional activation of the VEGF gene by okadaic acid. Cardiovasc Pathobiol 1:145-146.

Hilal-Dandan R, Ramirez MT, Villegas S, Gonzalez A, Endo-Mochizuki Y, Brown JH and Brunton L. (1997)

EndothelinETA receptor regulates signaling and ANF gene expression via multiple G protein-linked pathways. Am J Physiol 272:H130-H137.

Hilal-Dandan R, Villegas S., Gonzalez A and Brunton L (1997) The quasi-irreversible nature of endothelin binding and G protein-linked signaling in cardiac myocytes. J Pharmacol Exp Therap 281:267-273.

Kanter J and Brunton LL (1997) -adrenergic-forskolin synergy and stable changes in adenylyl cyclase in rat ventricular myocytes. Cardiovasc Pathobiol 2:37-42.

Martin JL, Mestril R, Hilal-Dandan R, Brunton LL and Dillmann W (1997) Small heat shock proteins and protection against ischemic injury in cardiac myocytes. Circulation 96:4343-4348.

Hilal-Dandan R, Harootunian AT and Brunton LL. (1998) Assessment of Cyclic AMP transients in single rat cardiac myocytes by microinjection of a fluorescent probe. Cardiovasc Pathobiol 2:129-134.

Narayana N, Diller TC, Koide K, Bunnage ME, Nicolaou KC, Brunton LL, Xuong N-H, Ten Eyck LF and Taylor SS. (1999) Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry 38:2367-2376.

Setyawan J, Koide K, Bunnage ME, Diller TC, Taylor SS, Nicolaou KC and Brunton LL. (1999) Inhibition of Protein

Kinases by Balanol: Specificity within the Ser/Thr Protein Kinase Subfamily. Mol. Pharmacol 56: 370-376.

Gustafsson ÅB and Brunton LL (1999) Differential and Selective Inhibition of PKA and PKC in Intact Cells by Balanol Congeners. Mol Pharmacol 56: 377-382.

Meszaros JG, Gonzalez AM, Endo-Mochizuki Y, Villegas S, Villarreal F and Brunton LL (2000) Identification of G-protein coupled signaling pathways in cardiac fibroblasts: Cross-talk between Gq and Gs. Am J Physiol 278: C154-C162.

Hilal-Dandan R., Kanter, JR and Brunton LL (2000) Characterization of G-protein Signaling in Ventricular Myocytes from the Adult Mouse Heart: Differences From the Rat. J Mol Cell Cardiol 32:1211-1221.

Meszaros JG, Lio F, Raphael R and Brunton LL (2000) Protein kinase C contributes to rapid desensitization of angiotensin II signaling in rat cardiac fibroblasts. Am. J. Physiol. 279:C1978-C1985.

Zambon AC, Hughes RJ, Meszaros JG, Wu JJ, Torres B, Brunton LL, and Insel PA. (2000). Canine P2Y2 receptor cloning and cell specificity of signal transduction mechanisms. Am J Physiol 279: F1045-F1052.

Gustafsson ÅB and Brunton LL (2000). Regulation of the Expression of Inducible Nitric Oxide Synthase in Adult Rat Cardiac Fibroblasts by IL-β and β-Adrenergic Stimulation. Mol Pharmacol 58:1470-1478.

Steinberg SF and Brunton LL. (2001) Compartmentation of G-protein-coupled Signaling Pathways in Cardiac Myocytes. Annu Rev Pharmacol Toxicol 41:751-73.

Zambon AC, Brunton LL, Barrett KB, Hughes RJ, Torres B and Insel PA. (2001) Cloning, expression, signaling mechanisms and membrane targeting of P2Y11 receptors in cultured MDCK-D1 cells. Mol Pharmacol 60:26-35.

Gustafsson ÅB and Brunton LL (2002). Attenuation of cyclic AMP accumulation in adult rat cardiac fibroblasts by IL-1β and nitric oxide: role of cGMP-stimulated phosphodisterase (PDE2). Am J Physiol Cell 283: C463-C471.

Beavo JA and Brunton LL (2002). Cyclic Nucleotide Research-still expanding after half a century. Nature Mol Cell Bio 3: 710-718.

Reiner DS, Hetsko ML, Meszaros JG, Sun C-H, Morrison HG, Brunton LL, Gillin FD (2003). Calcium Signaling in Excystation of the Early-Diverging Eukaryote, Giardia lamblia. J Biol Chem 278: 2533-2540.

Ostrom RS , Naugle JE, Hase M , Gregorian C, Swaney JS, Insel PA, Brunton LL and Meszaros JG (2003) Angiotensin II enhances adenylyl cyclase signaling via calcium-calmodulin: Gq-Gs crosstalk regulates collagen production in cardiac fibroblasts. J Biol Chem 278: 24461-24468.

Suarez J, Belke DD, Gloss B, Dieterle T, McDonough PM, Kim Y-K, Brunton LL and Dillmann WH. (2003) In vivo adenoviral transfer of sorcin reverses the cardiac contractile abnormalities of diabetic cardiomyopathy. Am J Physiol, in press, 9/03

Saucerman JJ, Brunton LL, Michailova AP, and McCulloch AD (2003) Analysis of β-adrenergic control of cardiac myocyte contractility in silico. J.Biol Chem 278: 47997-48003.

Brunton LL (2003) PDE4: Arrested at the Border - Compartmentation of cAMP signaling via phosphodiesterase recruitment by -arrestin. Science stke 2003 (204), pe44.

Gustafsson ÅB and Brunton LL (2004). Interactions of the Cyclic AMP and Nitric Oxide Pathways in Cardiac Fibroblasts. ISHR Proceedings (Pathophysiology of Cardiovascular Disease), 109-123.

Hilal-Dandan R, Means C, Gustafsson Å, Morissette M, Adams J, Brunton LL and Brown JH. (2004) Lysophosphatidic acid Induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol 36; 481-493.

Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves J, Xuong N, Taylor SS (2004) Balanol analogs probe specificity determinants and conformational malleability of cyclic AMP-dependent protein kinase catalytic subunit. Biochemistry 43: 85-96.


Relevant Books and Book Chapters

Brunton, LL (1997). Endothelin Receptor-Effector Coupling and Signalling in Cardiac Cells. In: Endothelial Modulation of Cardiac Function (eds., Lewis, MJ and Shah, AM), Harwood , Amsterdam, pp 125-138.

Meszaros G, Brunton LL and Bloor CM (1999). Animal Models of Angiogenesis in Cardiovascular Tissues. In: Angiogenesis and Cardiovascular Disease (eds., Ware and Simons), Oxford University Press, Oxford, pp 213-237.

Epperson SA, Gustafson ÅB, Gonzalez, Villegas S, Meszaros JG and Brunton LL. (2004) Pharmacology of G-Protein-linked Signaling in Cardiac Fibroblasts. In: Interstitial Fibrosis and Heart Failure (ed,Villarreal FJ), Kluwer, Boston: 83-97.

Brunton, LL (2005). Goodman and Gilman’s The Pharmacological Basis of Therapeutics (L. L. Brunton, editor-in chief), McGraw-Hill, New York, in preparation.

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Pozos, Robert S.
Department of Biology

The complete CV is available in PDF format.

Education
Southern Illinois University, Carbondale, IL:
Ph.D. Physiology / Biophysics 1969
Major Professor: Dr. A.W. Richardson,
Professor of Physiology and Biophysics

Southern Illinois University, Carbondale, IL:
M.A. Physioogy / Biophysics 1967
St. Louis University, St. Louis, Missouri, 1964-1966
Major Advisor: Dr. A.W. Richardson
Professor of Physiology

St. Mary's College, Moraga, California
B.S. Biology 1964


Positions and Honors
n/a

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