Fellows
|
Current | Alumni Leonel Villa Caballero Edgar Gutierrez Toni Jones Vicente M. Reyes Miguel T. Robinson |
Edgar Gutierrez Ph.D. |
Education
B.S., 1997, Chemical Engineering, University of California, Los Angeles
Ph.D., 2004, Bioengineering, University of California, San Diego (mentor, Amy Sung)
Employment
Postdoctoral Scholar
Microfluidics/Vascular System Cell Dynamics, UCSD (mentor, Alex Groisman), 2004-present
Research Interests
After receiving a PhD. in bioengineering with a focus on red blood cell lifespan and senescence, I pursued my interests in microfluidics studying vascular system cell dynamics. Specifically, I have worked on the development of silicon microfluidic devices and automated motion/ image acquisition systems for high-throughput cell assays. Projects include the development of microfluidic binding assays to test the strength of activated neutrophil adhesion to a matrix substratum as a measurement of inflammation and studies of transgenic platelet adhesion dynamics to diverse matrix proteins. Other projects include the development of a magnetic clamping platform to allow live-tissue conditions for long-term perfusion studies of endothelial cells and patterning of matrix molecules for neutrophil rolling studies.
Publications
Gutierrez E, Tkachenko E, Groisman A (2008). An easy to assemble microfluidic perfusion chamber with a magnetic clamp. Lab On A Chip. (In Preparation)
Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Groisman A, Zhang J, Tsien RY, Ginsberg MH (2008). Integrin-mediated Protein Kinase A Activation at the Leading Edge of Migrating Cells. (Submitted)
Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A (2008). Microfluidic Devices for Studies of Shear-Dependent Platelet Adhesion. Lab On A Chip. (In Press)
Goldfinger L, Tzima E, Stockton R, Kiosses WB, Kimbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH (2008). Localized a4 Integrin Phosphorylation Directs Shear Stress-Induced Endothelial Cell Alignment. Circ Res. (In Press)
Gutierrez E and Groisman A (2007). Quantitative measurements of the strength of adhesion of human neutrophils to a substratum in a microfluidic device. Analytical Chem 79, 2249-58.
Gutierrez E and Sung AL (2007).Interactions of Recombinant Mouse Erythrocyte Transglutaminase with Membrane Skeletal Proteins. J. of Membr Bio 219, 93-104.
Jiang L, Wang J, Solorzano-Vargas RS, Tsai HV, Gutierrez EM, Ontiveros LO, Kiela PR, Wu SV, Martin MG (2004). Characterization of the rat intestinal Fc receptor (FcRn) promoter: transcriptional regulation of FcRn gene by the Sp family of transcription factors. Am J Physiol Gastrointest Liver Physiol 286, G922-31.
Li TW, Wang J, Lam JT, Gutierrez EM, Solorzano-Vargus RS, Tsai HV, Martin MG (1999). Transcriptional control of the murine polymeric IgA receptor promoter by glucocorticoids. American J. of Physiol 276, G1425-34.
Martin MG, Wang J, Li TW, Lam JT, Gutierrez EM, Solorzano-Vargas RS, Tsai AH (1998). Characterization of the 5'-flanking region of the murine polymeric IgA receptor gene. American Journal of Physiology 275, G778-88.
Martin MG, Gutierrez EM, Lam JT, Li TW, Wang J (1997). Genomic cloning and structural analysis of the murine polymeric receptor (pIgR) gene and promoter region. Gene 201, 189-97.
Recent Teaching:
Bio100 Lectures - Immunology, Inflammation, Capillary Dynamics (3 lectures)
Contact Information:
Department of Physics 0374
UCSD
9500 Gilman Drive, 7233 Urey Hall
La Jolla, CA 92093-0374
Email: edgutier@ucsd.edu