Fellows
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Current | Alumni Leonel Villa Caballero Edgar Gutierrez Toni Jones Vicente M. Reyes Miguel T. Robinson |
Toni Jones-Cordero |
Employment
Staff Scientist - Amylin Pharmaceuticals (4/14/2008-Present)
Assistant Project Scientist - UCSD, Department of Anesthesiology (2007-2008)
Education and Training
Postdoctoral Fellow, 2003-2007, UCSD, Department of Anesthesiology, (Mentor, L. S. Sorkin)
Ph.D., 2003, Pharmacology, University of Illinois-Chicago, (Mentor, D. C. Yeomans)
B.S., 1996, Biological Sciences, University of Illinois-Chicago
Research Interests
In 2003, I completed my doctoral thesis in the laboratory of David C. Yeomans, Ph.D., Director of Pain Research at Stanford University, where I helped demonstrate that recombinant herpes simplex virus-type 1 (HSV-1) encoding sense or antisense cDNA can effectively alter nociceptive responses. After graduation, I began my post-doctoral training in the laboratory of Linda S. Sorkin, Ph.D., and investigated the development and maintenance of spinal-mediated pain behaviors; specifically, pain models invoking spinal sensitization. In 2006, I was awarded an NIH Pathway to Independence Award for my proposal entitled, Spinal cord signal transduction in a rat model of post-surgical pain. Studies within this proposal derived from the fact that more than half of surgery patients continue to report moderate to severe pain, even after administration of current analgesics. To investigate the return of function in the aging human, I employ middle-aged rats post-surgery, expecting that the model’s physiology would correspond to that in the aging human. For instance, as the rate of participation in the labor force by men and women ages 60 and older steadily increases, a new complication will emerge in which greater numbers of older patients undergoing surgery will need to return to work and quality of life. If the current methods of analgesia inadequately manage postoperative pain, they will most certainly be insufficient for the growing aging population. Recently, I moved to the private sector where I continue research focusing on spinal-mediated pain and novel therapeutics.
Publications (last 5 years)
Nagakura Y, Jones TL, Malkmus S, Sorkin LS, Yaksh, TL. The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy. Pain-D-08-4237R1.
Jones TL, Lustig AC and Sorkin LS. Secondary hyperalgesia in the postoperative pain model is dependent on spinal CaMKIIa. Anesthesia and Analgesia, 105, 1650- 1656, 2007.
Jones TL, Hefferan MP, Marsala M and Sorkin LS. Low-speed subcellular fractionation method for determining noxious stimulus-evoked spinal neurokinin-1 receptor internalization. Journal of Neuroscience Methods, 161, 23-31, 2006.
Boyle DL, Jones TL, Hammaker D, Svensson CI, Sorkin LS and Firestein GS. Regulation of peripheral inflammation by spinal p38 MAP kinase. PLoS Medicine, 3, 1-9, 2006.
Svensson CI, Schäfers M, Jones TL, Yaksh TL, Sorkin LS. Covariance among age, spinal p38 MAP kinase activation and allodynia. J Pain, 7 , 337-45, 2006.
Jones TL and Sorkin LS. Activated PKA and PKC, but not CaMKIIa, are required for non-NMDA receptor-mediated pain in the thermal stimulus model. Pain, 117, 259-70, 2005.
Jones TL, Sweitzer SM, Peters M, Wilson SP and Yeomans DC. GABAB receptors on central terminals of C-nociceptors mediate intersegmental Ad-nociceptor-evoked hypoalgesia: an antisense herpes vector study. Euro J Pain, 9, 233-342, 2005.
Svensson CI, Schäfers M, Jones TL, Powell H and Sorkin LS. Spinal blockade of TNF blocks SNL-induced increases in spinal P-p38. Neurosci Lett, 379, 209-213, 2005.
Jones TL and Sorkin LS. Calcium-permeable AMPA/KA receptors mediate development, but not maintenance, of thermal injury-evoked spinal sensitization in the rat. J Pharmacol Exp Therap, 310, 223-229, 2004.
Yeomans DC, Jones TL, Laurito CE, Lu Y and Wilson SP. Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin. Molecular Therapy, 9 , 24-29, 2004.
Jones TL, Sweitzer SM, Peters M, Wilson SP and Yeomans DC. Afferent fiber-selective shift in opiate potency following targeted opioid receptor knockdown. Pain, 106, 365-371, 2003.
Jones TL and Sorkin LS. Basic neurochemistry of chemical sensitization. Seminars in Pain Medicine, Editor, Patrick M. Dougherty, 1, 184-194, 2003.
Recent Teaching
Anatomy and Physiology Laboratory, CSU San Marcos, August 2007-present
Bio100 Lectures – Pain, Respiratory System, Somatic and Autonomic Nervous System, and Nervous System (4 lectures)
Neuroscience - Mechanisms of Pain, UCSD, Guest Lecturer
Honors
National Institutes of Health, NIGMS, Spinal cord signal transduction in a rat model of post-surgical pain, (T.L. Jones, K99 GM079921), 2006-2008.
United Negro College Fund-Merck & Co. Post-doctoral Science Initiatives Fellow, September 2004-2006.
Contact Information:
Email: tljones@ucsd.edu