Faculty

My interests in the area of the Pharmacology Department and for campus as a whole are to establish new research and education opportunities in novel interdisciplinary science programs that exploit existing faculty research strengths. For Pharmacology, my goals include developing a Center for Molecular Recognition, beginning with studies on drug docking, and facilitating the establishment of programs exploiting pharmaco-genomics. My own research has focused on structure-function relationships in protein-nucleic acid complexes and the architecture of chromatin and ribonucleoproteins. Over the past decade, I was involved in developing a series of programs for the federal government, from collaborating on the first stages of the genome project to establishing the first federal programs in bioinformatics and in computational biology, as well as new interdisciplinary training programs. My primary responsibilities at the University of California San Diego are to serve as part of the campus academic leadership team in establishing priorities and undertaking new initiatives, in developing and implementing new research and training programs in science and engineering. Pharmacology should benefit strongly from new computational science thrusts on the campus and from the coordinated effort in structural genomics, a second phase of international genome projects aimed at using physical science tools to uncover the information content of newly discovered genetic information. I look forward to finding collaborative efforts with the Pharmacology Department and in particular to bringing together computational science and experimental pharmacology to explore major ques-tions in the mechanisms for molecular recognition.

Most relevant to my immediate goals is a review paper I edited on a broad range of opportunities for computational science to contribute to experimental biology; this review is found at http://cbcg.lbl.gov/ssi-csb/Program.html; an over-view document is also hyperlinked at that site, as are view graphs on next generation biology, the requirements for next generation computing.

SELECTED PUBLICATIONS:

Chung, S. and Wooley, J. (1997), "The Likely Impact of Developments in Computer-based information, Networking and Research: A Perspective from the Biological Sciences," in Equipping Science for the 21^st Century, ed. John Irvine, Ben Martin, Dorothy Griffiths and Roel Gathier, Edward Elgar Press, Cheltenham, United Kingdom.

Head-Gordon, T. and Wooley, J., eds (1998) "A Community White Paper on Requirements for Advanced Computing for the Molecular Biosciences." url: cbdg.lbl.gov/ssi-csb/ Program. html.

Wooley, J. (1998) "Next Generation Biology-the Requirements for Next Generation Computing." Report to NSF, NIH, DOE, summer 1998 and url: cbcg.lbl.gov/ssi-csb/index.html and available from any of the agencies.

Wooley, J. and Head-Gordon, T. (1999) Advanced Computational Structural Geno-mics url: cbcg.lbl.gov/ssi-csb//index.html

Head-Gordon, T. and Wooley, J. (2001), "Computational Challenges in Structural and Functional Genomics" in the IBM Systems Journal, Vol 40, No 2.

Wooley, J. (1999), "Trends in Computational Biology: A Summary Based on a RECOMB Plenary Lecture, 1999" in the Journal of Computational Biology, Volume 6, Numbers 3/4, Mary Ann Liebert, Inc. pp. 459-474.