Faculty

• President, retired, Parke Davis/Warner Lambert Co., Pharmaceutical Research Division.
• Adjunct Professor of Pharmacology & Medicine

Key words: Affinity chromatography, protein chemistry, ligand-protein interactions, membrane receptors, signal transduction, hormone action, insulin, diabetes, drug discovery and development

Interests and expertise have focused primarily on the development and applications of affinity chromatography, the mechanism of action of membrane-bound receptors, the structure and function of the insulin receptor and its intracellular biochemical coupling, and signal transduction, particularly for growth factors. Also, I have had thirty years of personal involvement in the discovery, development and regulatory (FDA) approval of new drugs, in a variety of therapeutic areas, including diabetes mellitus, HIV, herpetic and bacterial infections, dyslipidemias, epilepsy, depression, Alzheimer's disease, cancer and contraception.

Selected Publications:

Hollenberg MD, Cuatrecasas, P. Insulin and epidermal growth factor: Human fibroblast receptors related to DNA synthesis and amino acid uptake. J Biol Chem1975; 250:3845-53.

Sheehter Y, Hernaez L, Sehlessinger J, Cuatrecasas P. Local aggregation of hormone-receptor complexes is required for activation by epidermal growth factor. Nature 1979;278:835-38.

Parikh 1, Cuatrecasas, P. Affinity chromatography. Chem and Engr News 1985; 63(34):17-32.

Saltiel AR, Cuatrecasas, P. Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Proc Natl Acad Sci USA 1986;83(16):5793-97.

Saltiel A, Fox J, Sherline P, Cuatrecasas, P. Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of CAMP phosphodiesterase. Science 1986;233:967-72.

Lazar, D., Knez, J., Medof, M., Cuatrecasas, P., and Saltiel, A. (1994) Stimulation of glycogen synthesis by insulin in human erythroleukiemia cells requires the synthesis of glycosylphosphatictylinositol. Proceedings National Academy of Sciences, Vol. 91, 9665-9.
 

Cuatrecasas, P. (1995) Corporate America: Creativity Held Hostage. Creative Action in Organizations, edited by Cameron M. Ford and Dennis A. Gioia, Sage Publications, Thousand Oaks, CA ; pp201-205.