|
|
|
May 16, 2008 |
|
 |
|||
 |
 |
 |
 |
 |
Faculty
TONY
L. YAKSH
- Professor of Anesthesiology and Pharmacology
- Vice Chair, Department of Anesthesiology
FAX: 619-543-6070
email: tyaksh@ucsd.edu
website: http://yakshlab.ucsd.edu
Ph.D., Purdue University
Key Words: Opioid Pharmacology; Analgesics; Pain
Our group has been examining the pharmacology and physiology of central and peripheral systems which regulate the transmission of high threshold sensory information (pain). Of particular interest is the release of neuropeptides and prostanoids from sensory afferents and spinal cord and the receptor systems which regulate this release.
Selected Publications:
Svensson CI, Fitzsimmons B, Azizi S, Powell HC, Hua XY, Yaksh TL. Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J Neurochem 92: 1508-1520, 2005.
Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci 25: 3651-3660, 2005.
Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia.Eur J Neurosci., 22:2431-40 2005
Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA.Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal PGE2 release. J Pharmacol Exp Ther.;316:466-75, 2006
Adams, Joseph A. Akassoglou, Katerina Bourne, Philip E. Brown, Joan Heller Brunton, Laurence L. Dennis, Edward A. Dixon, Jack E. Evans, Sylvia Feramisco, James R. Guan, Kun-Liang Hook, Vivian Insel, Paul A. Karin, Michael Leffert, Hyam L. McCammon, J. Andrew Newton, Alexandra C. Printz, Morton P. Taylor, Palmer Taylor, Susan Tsien, Roger Y. Tukey, Robert H. Yaksh, Tony L. Yang, Jing Khan, Imran M. Seasholtz, Tammy M. Williams, David S. Abraham, Robert T. Bartfai, Tamas Bonneville, Anne K. Chun, Jerold J. M. Crooke, Stanley T. Cuatrecasas, Pedro Evans, Ronald M. Stevens, Charles F. TenEyck, Lynn F. Vallon, Volker Venter, J. Craig Verkhivker, Gennady Wooley, John C.
|
