Pharmacology

May 13, 2008

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BMS/Pharmacology Orientation Retreat

September 24, 2007

Pharmacology Weekly Research Discussions

2007-2008; 2006-2007; 2005 - 2006; 2004 - 2005; 2003 - 2004

Pharmacology Seminar Course (PHAR 275):

Pharmacogenetics and Drug Metabolism (Winter 2008)

Pharmacology Seminar Series

2007-2008

Monday, September 24, 2007, 4:00pm, CMG Auditorium
Speaker: Estela Jacinto, Ph.D.
UMDNJ Dept. of Physiology/Biophysics
Target of Rapamycin (TOR) Signaling in Yeast and Mammals

Thursday, October 11, 2007, 2:00pm, Leichtag Bldg, Room 107
Speaker: Miles D. Houslay, Ph.D.
University of Glasgow
"Who's My New Best Friend? Partners for PDE4 Phosphodiesterases That Underpin Compartmentalized cAMP Signaling: Beta-arrestin, RACK1 and DISC1"

Tuesday, October 30, 2007, 12:00pm, Leichtag Bldg, Room 107
Speaker: George Kunos, M.D., Ph.D.
Scientific Director, NIAAA/NIH
"Endocannabinoids and the Control of Energy Homeostatsis Viral hijacking of G-Protein signaling networks in AIDS-malignancies"

Tuesday, November 13, 2007, 12:00pm, Leichtag Bldg, Room 107
Speaker: Silvio Gutkind, Ph.D.
NIH
"Viral hijacking of G-protein signaling networks in AIDS-malignancies and vascular permeability: What have we learned?"

Wednesday, December 5, 2007, 4:00pm, Leichtag Bldg, Room 107
Speaker: Susan Steinberg, M.D.
Columbia University
"Protein Kinase C-delta Signaling Mechanisms in Cardiomyocytes. Rules of phosphorylation .... or phosphorylation rules!"

Tuesday, December 11, 2007, 12:00pm, Leichtag Bldg, Room 107
Speaker: Bruce Hammock, Ph.D.
University of California, Davis
"The Epoxide Hydrolase as a Target for the Clinical Target for the Treatment of Hypertension, Inflammation and Pain"

Tuesday, January 8, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Steven Kliewer, Ph.D.
UT Southwestern
"Nuclear Receptors and Metabolic FGFs: From Feast to Famine"

Tuesday, January 15, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Howard McLeod, Pharm.D.
University of North Carolina
"Using the Genome to Optimize Drug Therapy"

Tuesday, January 22, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Frank Gonzalez, Ph.D.
NIH
"Metabolomics in Toxicology and Pharmacology"

Tuesday, January 29, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Ron Evans, Ph.D.
Salk Institute
"Nuclear Receptors: Molecular Engineering of Physiology"

Monday, February 4, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: J. Craig Venter, Ph.D.
J. Craig Venter Institute
"Genomics: From Humans to the Environment"

Tuesday, February 12, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Daniel O'Connor, M.D.
UCSD
"Functional Genomics of the Sympathetic Nervous System: Implications for Hypertension"

Tuesday, February 19, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Mark Ratain, M.D.
University of Chicago
"Pharmacogenetics of Irinotecan"

Thursday, February 21, 2008, 2:00pm, Leichtag Bldg, Room 107
Speaker: Urs A. Meyer, M.D.
University of Basel
"Nuclear Receptor Crosstalk and Regulation of Cytochromes P450""

Tuesday, February 26, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Eric Johnson, Ph.D.
The Scripps Research Institute
"Structural Genomics of the Human Drug Metabolizing Cytochrome P450 Monooxygenases"

Tuesday, March 4, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Nicholas Schork, Ph.D.
The Scripps Research Institute
"Pharmacogenomics and Personal Medicine: Theory and Practice"

Tuesday, March 11, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Alain Belanger, Ph.D.
Laval University
"Role of UGT2B15 in the Control of Androgen Action"

Thursday, March 13, 2008, 2:00pm, CMG Auditorium
Speaker: Sara Courtneidge, Ph.D.
The Burnham Institute for Medical Research
"Src, its substrates, and cancer cell invation"

Tuesday, March 18, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: David Moore, Ph.D.
Baylor College of Medicine
"CAR: Upstream and Downstream of Diabetes"

Thursday, April 10, 2008, 12:00pm, CMG Auditorium
Speaker: Susan Band Horwitz, Ph.D.
Albert Einstein College of Medicine
"Taxol, Tubulin and Tumors: Challenges in the New Era of Cancer Therapeutics"

Tuesday, April 29, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Curt Sigmund, Ph.D.
University of Iowa
"A Pivotal Role for PPARgamma in Regulating Vascular tone and Arterial Pressure"

Tuesday, May 13, 2008, 12:00pm, Leichtag Bldg, Room 107
Speaker: Dafna Bar-Sagi , Ph.D.
NYU School of Medicine
"Ras-Signaling: A Bird's Eye View"

Pharmacology Seminar Series

2006-2007

Tuesday, September 19, 2006, 4:00pm, CMG Auditorium
Speaker: Steven M. Sine, Ph.D.
Mayo Clinic College of Medicine
"Toward atomic-scale understanding of nicotinic receptor channel activation"

Tuesday, October 10, 2006, 12:00pm, Leichtag 107
Speaker: Timothy Hla , Ph.D.
University of Connecticut

Tuesday, November 7, 2006, 12:00pm, Leichtag 107
Speaker: David Sinclair, Ph.D.
Harvard Medical School

Friday, November 17, 2006, 12:00pm Liebow Auditorium
Speaker: Charles Serhan, Ph.D.
Brigham & Women's Hospital
"Novel Lipid Mediators in the Resolution of Inflammation: Resolvins and Protectins"

Wednesday, December 13, 2006, 4:00pm Leichtag 107
Speaker: Phil Barker, Ph.D.
McGill University
"Life, Death and the p75 Neurotrophin Receptor"

Tuesday, December 19, 2006, 12:00pm Leichtag 107
Speaker: Melvin I. Simon, Ph.D.
University of California San Diego
"Adventures in G-protein Mediated Signal Transduction"

Tuesday, January 9, 2007, 12:00pm, Leichtag 107
Speaker: Ruslan Medzhitov, Ph.D.
Howard Hughes Medical Institute, Yale University School of Medicine
"Toll Signaling"

Tuesday, January 16, 2007, 12:00pm Leichtag 107
Speaker: Bruce Beutler, Ph.D.
The Scripps Research Institute
"Genetic Analysis of Innate Immune Sensing and Response"
http://www.scripps.edu/imm/beutler/index.html"

Tuesday, January 23, 2007, 12:00pm Leichtag 107
Speaker: Richard Ransohoff, Ph.D.
Neuroinflammation Research Center, Lerner Research Institute
"Neurobiology and Immunobiology of the Chemokine System"
http://www.lerner.ccf.org/neurosci/ransohoff/

Tuesday, January 30, 2007, 12:00pm, Leichtag 107
Speaker: Dan Littman, Ph.D.
Skirball Institute of Biomolecular Medicine, NYU School of Medicine
"Control of T-Cell Homeostasis by the Orphan Nuclear Receptor RoRyt"
http://med.nyu.edu/people/littmd01.html"

Tuesday, February 6, 2007, 12:00pm Leichtag 107
Speaker: Edward A. Dennis, Ph.D.
University of California, San Diego
"Profiling Inflammatory Mediators Through Eicosanoid Lipidomics"

Tuesday, February 13, 2007, 12:00pm Leichtag 107
Speaker: Eyal Raz, Ph.D.
University of California, San Diego
"Colonic Homeostasis vs. Colitis. The Role of TLR"

Tuesday, February 20, 2007, 12:00pm Leichtag 107
Speaker: Genhong Cheng, Ph.D.
University of California, Los Angeles
"Innate Anti-Bacterial and Anti-ViralGene Programs and their Crosstalk with Host Metabolism"
http://www.mimg.ucla.edu/faculty/cheng/genhong.html

Tuesday, February 27, 2007, 12:00pm Leichtag 107
Speaker: Geoff Rosenfeld , Ph.D.
University of California, San Diego
"Transcriptional Coactivators and Corepressors in Inflammatory Response"

Tuesday, March 6 , 2007, 12:00pm Leichtag 107
Speaker: CHANGED to Michael Karin, UCSD
"Receptors and Signaling Pathways Involved in Host Defense and Inflammatory Diseases"

Tuesday, March 13 , 2007, 12:00pm Leichtag 107
Speaker: Christopher Glass, Ph.D.
University of California, San Diego
"Nuclear Receptors and Inflammation"
http://cmm.ucsd.edu/glass/glasslab/chris.html

Tuesday, March 20, 2007, 12:00pm Leichtag 107
Speaker: Tracy M. Handel, Ph.D.
University of California, San Diego
"Chemokines and Inflammation"
http://pharmacy.ucsd.edu/faculty/handelbio.shtml

Thursday, April 5, 2007, 12:00pm CMG Auditorium
Speaker: Kun-Liang Guan
Life Sciences Institute, University of Michigan
"Regulation of Cell Growth and "Tumorigenesis by the mTOR and Hippo Pathways"

Monday, April 9 , 2007, 11:00am, PSB, Room 1120
Speaker: Julius Zhu, Ph.D.
University of Michigan
"Oncogenic Ras Signaling at Synapses"

Tuesday, April 10, 2007, 12:00pm, Leichtag Bldg, Room 107
Speaker: Paolo Sassone-Corsi, Ph.D.
University of California, Irvine
"A Chromatin Remodeling CLOCK"

Wednesday, April 11 , 2007, 12:00pm, PSB, Room 1186
Speaker: Michael Eddleston, Ph.D.
Wellcome Trust Clinician Scientist, Edinburgh University
"Clinical Problems of Organophosphorus Pesticide Poisoning"

Wednesday, April 18 , 2007, 12:00pm, PSB, Room 1120
Speaker: James Trimmer, Ph.D.
University of California, Davis
"Ion Channel Phosphorylation as Regulator of Neuronal Excitability"

Monday, April 23 , 2007, 12:00pm, PSB, Room 1120
Speaker: Sangwon Kim, Ph.D.
Johns Hopkins University, Department of Neuroscience
"Molecular Mechanism of Desire and Death: Antipsychotic Drug-Induced Weight Gain and GTPase Dexras 1-Mediated Iron Influx in the Brain"

Tuesday, April 24 , 2007, 12:00pm, PSB, Room 1120
Speaker: Camilla Svensson , Ph.D.
University of California, San Diego
"Inflammatory Pain: Role of MAPKs and Lipoxins"

Thursday, May 3, 2007, 12:00pm, CMG Auditorium
Speaker: JoAnn Trejo, Ph.D.
University of North Carolina at Chapel Hill
"Protease-activated Receptor-1 Signaling: A Trafficking Solution to a Signaling Problem"

Tuesday, May 22, 2007, 12:00pm Leichtag 107
Speaker: Morris J. Birnbaum, M.D., Ph.D.
Howard Hughes Medical Institute, Univ. of Pennsylvania School of Medicine
http://www.med.upenn.edu/crrwh/Birnbaum.html

2005-2006

Monday, September 19, 2005 4:00 pm Leichtag Building, Room 107
Speaker: Jeffrey A. Frost, Ph.D..
Department of Integrative Biology and Pharmacology University of Texas Health Science Center at Houston
Casting a wide Net: The Rho exchange factor NET1 in cytoskeletal regulation and cancer"

Thursday, September 22, 2005 1:00pm Leichtag Building, Room 107
Speaker: Alexander C. Zambon, Ph.D.
Gladstone Institute of Cardiovascular Disease University of California, San Francisco
"New Insights into Signaling and Cardiac Muscle Remodeling, using Microarrays, Pathway Analysis, and Transcription Factor Mapping"

Wednesday, October 26, 2005 12:00 pm Leichtag Building, Room 107 Speaker: Henning Schroeder, Ph.D.
Department of Pharmacology and Toxicology Martin Luther University - School of Pharmacy Visiting Professor, Department of Pediatrics, Stanford University
"Ferritin and Heme Oxygenase-1: Novel Drug Targets in Cardiovascular Disease"

Friday, October 28, 2005 2:00 pm Leichtag Building, Room 107

Speaker: Richard Neubig, M.D., Ph.D.
University of Michigan
"RGS Proteins and Ga Selective Signaling"

Tuesday, November 1, 2005 4:00pm CMG Auditorium

Speaker: Michael Rosen, Ph.D.
HHMI and Department of Biochemistry UT Southwestern Medical Center
"The Structural Basis of Formin Function and Regulation"

Tuesday, November 8, 2005 12:00pm CMG Auditorium

Speaker: Marcelo Kazanietz, Ph.D.
Chair, Graduate Group in Pharmacological Sciences, University of Pennsylvania School of Medicine
"Diacylglycerol Signaling: Looking Beyond PKC "

Wednesday, November 30, 2005 12:00 pm Leichtag Building, Room 107 Speaker: Dimitri Grigoriadis, Ph.D.
Neurocrine Fellow, VP Pharmacology & Lead Discovery, Neurocrine Biosciences, Inc.
"Molecular Mechanisms of Peptide and Non-Peptide Interactions with CRF1 Receptor"

Wednesday, December 7, 2005 2:00pm CMG Auditorium
Speaker: Patricia Babbitt, Ph.D.
Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry, UC San Francisco
"Pitfalls and Solutions for Assigning Function from Structural Similarities: Mechanistically Diverse Enzyme Superfamilies"

Tuesday, December 13, 2005 12:00pm, CMG Auditorium
Speaker: Olivier Civelli, Ph.D.
Professor of Neuropharmacology, Department of Pharmacology,
University of California, Irvine
"The search for novel neurotransmitters and the study of their functions"

Thursday, January 5, 2006 12:00pm, CMG Auditorium
Speaker: Pieter Dorrestein, Ph.D.
Department of Chemistry, University of Illinois at Urbana-Champaign
"Substrate and Activity Analysis of Non-Ribosomal and Polyketide Biosynthetic Pathways by Large Molecule Mass Spectrometry"

Tuesday, January 10, 2006 12:00pm, Liebow Auditorium
Speaker: Marc Tessier-Lavigne, Ph.D.
Senior Vice President, Research Drug Discovery at Genentech
"Wiring Nerves, Wiring Vessels: Common Mechanisms of Axon Guidance, Regeneration, and Vascular Patterning"

Tuesday, January 10, 2006 11:00am, CMG Auditorium

Speaker: Howard Hang, Ph.D.
Whitehead Institute of Biomedical Research, Massachusetts Institute of Technology
"Chemical tools for studying post-translational modifications in living cells"

Thursday, January 12, 2006 12:00pm, CMG Auditorium
Speaker: Jean-Philippe Pellois , Ph.D.
Laboratory of Synthetic Protein Chemistry, The Rockefeller University
"Caged proteins and photoactivation of signal transduction in live cells"

Thursday, January 12, 2006 2:00pm, Garren Auditorium
Speaker: Andrew Neuwald, Ph.D.
Associate Professor, Cold Spring Harbor Laboratory
"Predicting Critical Aspects of Biological Mechanisms through Bayesian Inference of Evolutionary Constraints"

Tuesday, January 17, 2006 12:00pm, CMG Auditorium
Speaker: Mark Tuszyniski, Ph.D. UCSD
Growth Factor Gene Delivery for Alzheimer's Disease

Monday, January 23, 2006 12:00pm, Leichtag 107
Speaker: Alan Saghatelian, Ph.D.
The Scripps Research Institute
"Assigning Endogenous Substrates to Enzymes by Global Metabolite Profiling"

Tuesday, January 24, 2006 12:00pm, CMG Auditorium
Speaker: Anthony Auerbach, Ph.D.
Professor, Departments of Physiology and Biophysics, SUNY at Buffalo
"The Acetylcholine Receptor Gating Nanomachine"

Tuesday, January 31, 2006 12:00pm, CMG Auditorium
Speaker: Greg Lemke, Ph.D.
Salk Institute
"Eph Receptors and the Formation of Topographic Neural Maps"

Thursday, February 1, 2006 12:00pm, Leichtag 107
Speaker: Dustin Maly, Ph.D.
Cellular and Molecular Pharmacology, UC San Francisco
"Mechanism-Based Chemical Tools for Studying Protease and Kinase Function"

Friday, February 3, 2006 12:00pm, Leichtag 107
Speaker: Elizabeth Woodcock, Ph.D.
Head of Cellular Biochemistry Laboratory, Baker Heart Research Institute, Melbourne, Australia
"Ins(1,4,5)P3 signaling in heart"

Tuesday, February 7, 2006, 12:00pm, CMG Auditorium
Speaker: Benjamin Cravatt, Ph.D
Scripps Institute
"The enzymatic regulation of endocannabinoid signaling and its therapeutic implications"

Tuesday, February 14, 2006, 12:00pm, CMG Auditorium
Speaker: Tony Yaksh , Ph.D
Professor of Anesthesiology and Pharmacology, UCSD
"Microglia and regulation of the excitability of spinal systems which mediate pain processing"

Tuesday, February 21, 2006, 12:00pm, CMG Auditorium
Speaker: George Koob, Ph.D
Scripps Institute
"The Neurocircuity of Drug Addiction: Neuroadaptive Mechanisms within the Brain Reward and Stress Systems"

Thursday, March 2, 2006, 2:00pm, Leichtag 107
Speaker: Christine Vogel, Ph.D
Institute for Cellular and Molecular Biology, UT at Austin
"A domain perspective on the evolution of the protein repertoire"

Tuesday, March 7, 2006, 4:00pm, CMG Auditorium
Speaker: Arthur Grollman, Ph.D
Dept. of Pharmacology, SUNY at Stonybrook
"Environmental Etiology of Endemic Nephropathy; Toxicogenomics of a Multinational Disease"

Friday, March 10, 2006, 12:00pm, CMG Auditorium
Speaker: Mark Ellisman, Ph.D
UCSD
"Multiscale Imaging of the Brain: Where's the Dark Matter?"

Tuesday, March 14, 2006, 12:00pm, CMG Auditorium
Speaker: Moses V. Chao, Ph.D.
Professor of Cell Biology; Physiology & Neuroscience, NYU
"Upstream and Downstream of Neurotrophin Receptors"

Tuesday, March 21, 2006, 4:00pm, CMG Auditorium
Speaker: Fred Gage, Ph.D.
Salk Institute
"Regulation and Function of Stem Cells in the Adult Nervous System"

Friday, March 24, 2006, 3:00pm, Leichtag 107
Speaker: Peng Wang, Ph.D
University of Georgia
"Structural genomics analysis of alternative splicing and the discovery of splicing regulatory elements"

Thursday, March 30, 2006, 12:00pm, Leichtag 107
Speaker: JoAnn Trejo, Ph.D.
Dept. of Pharmacology, University of North Carolina at Chapel Hill
"Protease-activated Receptor Signaling and Mechanisms of Endocytic Sorting"

2004-2005

Wednesday, March 30, 4:00pm – Leichtag 107
Inaugural BMS Student Seminar
Speaker: Richard Palmiter
Professor of Biochemistry, University of Washington, Seattle
"Dopamine, Motivation and Reward"

Thursday, March 31, 4:00pm – Leichtag 107
Pharmacology Seminar
Speaker: Donald Bers
Professor and Chairman, Cellular and Molecular Physiology, Loyola University Medical Center
"Ca and CaMKII: Local control in EC Coupling and transcriptional regulation"

Wednesday, April 6, 4:00pm – Leichtag 107
Pharmacology and Chem/Biochem Recruitment Seminar
Speaker: Fei Wang
Department of Cellular and Molecular Pharmacology
University of California, San Francisco
"Neutrophil Polarity and Chemotaxis: Dissecting the Signaling Network"

Tuesday, April 12, 12:00pm – CMG Auditorium
Pharmacology Seminar Series
Speaker: Chris Glembotski
Professor and Chairman of Biology, San Diego State University
Director, SDSU Heart Institute
"Signaling Pathways that Mediate Protective Stress Responses"

Thursday, April 21, 12:00pm – Leichtag 107
Pharmacology Seminar
Speaker: Helen Blau
Director, Baxter Laboratory in Genetic Pharmacology
Professor, Departments of Microbiology and Immunology and Molecular Pharmacology Stanford University School of Medicine
Plasticity, Reprogramming and Stem Cells

Tuesday, April 26, 12:00pm – CMG Auditorium
Pharmacology and Chem/Biochem Recruitment Seminar
Speaker: Matthew Petroski
Division of Biology, California Institute of Technology
A means to an end: Destruction of Sic1, an SCF ubiquitin ligase substrate

Friday, May 27, 2005 4:00PM – Leichtag Building, room 107
Speaker: Ze'ev Ronai, Ph.D.
Program Director, Signal Transduction
Burnham Institute
"RING finger E3 ligase Siah in hypoxia and stress response"

2003-2004

Research Focus Areas

Signal Transduction

Computational Biology and Drug Design

Integrated System and Animal Models

Pharmacogenomics