Distinguished Professor of Pharmacology
Ph.D., Purdue University
Key Words: Phosphorylation, signal transduction, tumor suppressor, mTOR, TSC, Hippo
The research in Dr. Guan’s laboratory focuses on two topics, the TSC-mTOR pathway and the hippo-YAP pathway. The TSC-mTOR pathway plays a major role in cell growth regulation and dysregulation of this pathway has been frequently observed in human cancers. Studies from the Guan lab have contributed to the mTOR signaling network. Current research includes mTOR regulation by nutrient signals and stress. Study from the Guan lab has also revealed the mechanism of the YAP oncoprotein regulation by the Hippo tumor suppressor pathway, which controls tissue homeostasis, organ size control, and tumorigenesis. Recent observations show that the Hippo-YAP pathway is dynamically regulated by G-protein coupled receptor signaling.
Selected Publications | PubMed Listing
Yu, F-X., Zhao, B., Panupinthu, et al., and Guan, K-L. (2012) Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling. Cell 150, 780-91.
Kim, J., Kim, Y.C., Fang, C., et al., Guan, K-L. (2013) Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303.
Russell, R.C., Tian, Y., Yuan, H., et al., Guan, K-L. (2013) ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase. Nature Cell Biol. 15, 741-50.
Jewell, J.L., Kim, Y.C., et al., and Guan, K-L. (2015) Differential Regulation of mTORC1 by Leucine and Glutamine. Science 347, 194-198.
Park, H. W., Kim, Y.C., et al., and Guan, K-L. (2015) Alternative Wnt Signaling Activates YAP/TAZ . Cell 162, 780-794
Yu, F.X., Zhao, B., and Guan, K-L. (2015) Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell 163, 811-828.