Assistant Professor of Pharmacology and Medicine
MD, PhD Boston University School of Medicine
Phone: (858) 822-5854
Lab website: www.jainlaboratory.org
Key Words: Metabolomics, mass spectrometry, integrative biology, metabolic biochemistry, human biology
Diverse environmental exposures - including host factors, microbiota, dietary components, drugs, toxicants and pollutants – serve as critical drivers of human physiology and disease. These exposures introduce small molecule mediators into human circulation which in turn result in protein / DNA modification, altered cell signaling, and dysregulation of cellular metabolism. Our laboratory at UC San Diego utilizes cutting edge mass spectrometry based metabolomics in conjunction with population scale human biosamples and large-scale data integration to map the environmental landscape of human disease. In addition, we make use of genome engineering and cellular, fish and animal models to define the mechanisms and metabolic consequences of disease. Our laboratory consists of an interdisciplinary team with diverse expertise encompassing analytical chemistry, high-throughput biology, computational biology, metabolic biochemistry, cellular biology, biomedical and clinical epidemiology. Our work is performed in close collaboration with a team of investigators based at UC (San Diego), Harvard Medical School (Boston) and Karoliska Institute (Stockholm).
Selected Publications | PubMed Listing
Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolic profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 336:1040-4. 2012.
Nilsson R*, Jain M*, Madhusudhan N, Gustafsson Sheppard N, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nature Commun. 5:3128. 2014.
Jain M, Ngoy S, Sheth S, Swanson R, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R. A systematic survey of lipids across mouse tissues. Am J of Physiol Endocrinol Metab. 306:E854-68. 2014.