Anne Murphy Associate Adjunct Professor of Pharmacology Ph.D., The George Washington University School of Medicine Phone: 858-822-4007 Fax: E-mail: anmurphy@ucsd.edu

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After receiving my graduate degree from The George Washington University School of Medicine (Washington, D.C.), and post-doctoral training at The Johns Hopkins School of Medicine (Baltimore, MD), and The National Cancer Institute (Bethesda, MD), I became an Assistant Professor of Biochemisty and Molecular Biology at GWU, where my research group focused on the mechanism of protection of mitochondrial by the antiapoptotic protein Bcl-2. Next, I became the Director of Mitochondrial Biology at MitoKor in the biotech industry, where my research group concentrated on mitochondrial target-based drug development for neurodegenerative diseases, type II diabetes, and osteoarthritis. In 2005, I joined the efforts of Dr. Dixon's laboratory to reveal the molecular mechanisms of integration of mitochondrial function into cellular signaling cascades.

Recent Publications

Murphy, A.N., Kelleher, J.K., and Fiskum, G. (1990) Submicromolar Ca2+ regulates phosphorylating respiration by normal rat liver and AS-30D hepatoma mitochondria by different mechanisms. J. Biol. Chem. 265:10527-10534.

Murphy, A.N., Unsworth, E.J., and Stetler-Stevenson, W.G. (1992) TIMP-2 inhibits human microvascular endothelial cell proliferation. J. Cell. Physiol. 157:351-358.

Aznavoorian, S., Murphy, A.N., Stetler-Stevenson, W.G., and Liotta, L.A. (1993) Molecular aspects of tumor cell invasion and metastasis. Cancer 71:1368-1383.

Myers, K.M., Fiskum, G., Liu, Y., Simmens, S.J., Bredesen, D.E., and Murphy, A.N. (1995) Bcl-2 protects neural cells from cyanide/aglycemia induced lipid oxidation, mitochondrial injury, and loss of viability. J. Neurochem. 65:2432-2440.

Ellerby, L.M., Ellerby, H.M., Park, S.M., Holleran, A.L., Murphy, A.N., Fiskum, G., Kane, D.J., Testa, M.P., Kayalar, C., and Bredesen, D.E. (1996) Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J. Neurochem. 67:1259-1267.

Murphy, A.N., Bredesen, D.E., Cortopassi, G., Wang, E., and Fiskum, G. (1996) Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc. Natl. Acad. Sci. USA 93: 9893-9898.

Murphy, A.N., Fiskum, G., and Beal, M.F. (1999) Mitochondria in Neurodegeneration: Bioenergetic function in cell life and death. J. Cerebral Blood Flow & Metab. 19:231-245.

Fiskum, G., Murphy, A.N., and Beal, M.F. (1999) Mitochondria in Neurodegeneration: Acute ischemia and chronic neurodegenerative diseases. J. Cereb. Blood Flow & Metab. 19: 351-370.

Murphy, A.N. (2000) Mitochondria in human disease. The Biochemist 22: 29-34.

Johnson, K., Jung, A., Murphy, A., Andreyev, A., Dykens, J., and Terkeltaub, R. (2000) Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization. Arthritis and Rheumatism 43:1560-1570.

Kushnareva, Y, Murphy, A.N., and Andreyev, A. (2002) Complex I mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem. J. 368:545-553.

Taylor, S.W., Fahy, E., Zhang, B, Glenn, G.M., Warnock, D.E., Wiley, S., Murphy, A.N., Gaucher, S.P., Capaldi, R.A., Gibson, B.W., and Ghosh, S.S. (2003) Characterization of the human heart mitochondrial proteome. Nat Biotechnol 21:281-6.

Johnson, K., Svensson, C.I., Van Etten, D., Ghosh, S.S., Murphy, A.N., Powell, H.C., and Terkeltaub, R. (2004) Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs. Arthritis and Rheumatism 50(4):1216-25.

Kushnareva, Y.E., Wiley, S.E., Ward, M.W., Andreyev, A.Y., and Murphy, A.N. (2005) Excitotoxic injury to mitochondria isolated from cultured neurons. J. Biol. Chem. 280:28894-902.

Lee, J., Kim, C.H, Simon, D.K., Aminova, L.R., Andreyev, A.Y., Murphy, A.N., Lonze, B.E., Kim, K.S., Ginty, D., Ferrante, R.J., Ryu, H., and Ratan, R.R. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J. Biol. Chem. 280:40398-401.

Yamaguchi, R., Andreyev, A., Murphy, A.N., Perkins, G.A., Ellisman, M.H., and Newmeyer, D.D. (2006) Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity. Cell Death and Differentiation, (in press).