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Roger Tsien (Nobel Prize in Chemistry)
Professor of Pharmacology and Chemistry & Biochemistry
Investigator, Howard Hughes Medical Institute
Ph.D., University of Cambridge, England

Phone: 858-534-4891
Fax: 858-534-5270
E-mail: rtsien@ucsd.edu

Lab Website

Key Words: Signal Transduction; Calcium; Neurobiology

Protease-directed molecular targeting of contrast agents, radiation sensitizers, and drugs to tumors, atherosclerotic plaques, strokes, and arthritic joints. Delivery of hydrophilic drugs into the cytosol and across the blood-brain barrier. Fluorescence highlighting of myelin for image-guided surgery. Imaging newly synthesized proteins during synaptic plasticity and neuropathology. Genetically encoded transducers to stimulate neuronal firing in response to light or magnetic fields. Infrared-fluorescent proteins for imaging cell and molecular dynamics in thick tissues and organisms. Singlet-oxygen-generating proteins for electron microscopy, acute inactivation of proteins, and proximity sensing.

Recent Publications

Sakina F Palida, Margaret T Butko, John T Ngo, Mason R Mackey, Larry A Gross, Mark H Ellisman and Roger Y Tsien. 2015. PKMζ, But Not PKCλ, Is Rapidly Synthesized and Degraded at the Neuronal Synapse. J Neurosci 35(20):7736-49.

Lisa Buckel, Elamprakash N Savariar, Jessica L Crisp, Karra A Jones, Angel M Hicks, Daniel J Scanderbeg, Quyen T. Nguyen, Jason K Sicklick, Andrew M Lowy, Roger Y Tsien, and Sunil J Advani. Tumor radiosensitization by monomethyl auristatin e: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.

Jessica L Crisp, Elamprakash N Savariar, Heather L.Glasgow, Lesley G Ellies, Michael A Whitney, and Roger Y. Tsien. 2014. Dual targeting of integrin ανβ3¬† and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery. Mol Cancer Ther. 13: 1514-25

John Y Lin, Per M Knutsen, Arnaud Muller, David Kleinfeld, and Roger Y. Tsien. 2013. ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nat. Neurosci. 16: 1499-508.

Margaret T. Butko, Jin Yang, Yang Geng, Hyung Joon Kim, Noo Li Jeon, Xiaokun Shu, Mason R. Mackey, Mark H. Ellisman, Roger Y. Tsien, and Michael Z. Lin. 2012. Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy. Nat Neurosci.15(12): 1742-1751.

Xiaokun Shu, Varda Lev-Ram, Thomas J. Deerinck, Yingchuan Qi, Ericka B. Ramko, Michael W. Davidson, Yishi Jin, Mark H. Ellisman, Roger Y. Tsien 2011. A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms. PloSBiology, 9(4):e1001041.

Michael A Whitney, Jessica L Crisp, Linda T Nguyen, Beth Friedman, Larry A Gross, Paul Steinbach, Roger Y Tsien & Quyen T Nguyen 2011. Fluorescent peptides highlight peripheral nerves during surgery in mice. Nature Biotech: 29(4):352-6.

Emilia S. Olson, Tao Jiang, Todd A. Aguilera, Quyen T. Nguyen, Lesley G. Ellies, Miriam Scadeng, and Roger Y. Tsien 2010. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc. Natl. Acad. Sci. 107: 4311-4316.

Quyen T. Nguyen, Emilia S. Olson, Todd A. Aguilera, Tao Jiang, Miriam Scadeng, Lesley G. Ellies, and Roger Y. Tsien 2010. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves  survival. Proc. Natl. Acad. Sci. 107:4317-4322.

Main address: Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0636
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