Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci, 105:6386-91, 2008.
Rieg T, Pothula K, Schroth J, Osswald H, Schnermann J, Insel P, Bundey R, Vallon V. Vasopressin regulation of inner medullary collection ducts and compensatory changes in mice lacking Adenosine A1 receptor. Am J Physiol Renal Physiol, 294:F638-44, 2008.
Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, DrummondJ, Patel PM. Caveolin 1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and Erk ½ activation and protection of primary neurons from ischemic cell death. FASEB J, 22:828-40, 2008.
Horikawa Y, Patel HH, Tsutsumi YM, Jennings MM, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, Roth DM. Caveolin-3 expression and caveolae are required for volatile anesthetic-induced cardiac protectionfrom hypoxia and ischemia/reperfusion injury. J Mol Cell Cardiol, 44:123-30, 2008.
Swaney JS, Patel HH, Yokoyama U, Lai NC, Spellman M, Insel PA, Roth DM. Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction. Am J Physiol Heart Circ Physiol, 293:H3216-20, 2007.
Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V. Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J, 21:3717-26, 2007.
Corriden R, Insel PA, Junger W. A novel method using fluorescence microscopy for real time assessment of ATP release from individual cells. Am. J Physiol-Cell Physiology,293:C1420-5, 2007.
Patel HH, Zhang S, Murray F, Suda R, Head B, Swaney J, Niesman I, Schermuly R, Pullamsetti S, Thistlethwaite PA, Farquhar MG Yuan JX, Insel PA. Increased caveolin-1 and caveolae expression contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J, 21:2970-9, 2007.
Yip L, Cheung CW, Corriden R, Chen Y, Insel PA, Junger WG. Hypertonic stress regulates T-cell function bythe opposing actions of extracellular adenosine triphosphate and adenosine. Shock, 27: 242-250, 2007.
Steagall WK, Barrow BJ, Glasgow CG, Woo J, Ethrmantraut M, Lin J, Insel PA, Moss J. β2-adrenergic receptorpolymorphisms in cystic fibrosis. Pharmacogenetics and Genomics, 17:425-430, 2007.
Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA and Roth DM. Mechanisms of cardiac protection from ischemia/perfusion injury: a role for caveolae and caveolin-1. FASEB J, 21:1565-74, 2007.
Arthur DB, Taupenot L, Insel PA.Nerve growth factor-stimulated neuronal differentiation induces changes in P2 receptor expression and nucleotide-stimulated catecholamine release. J Neurochem,100:1257-64, 2007.
Murray, F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan, JX, Insel PA. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol, 292:294-303, 2007.
Rana BK, Insel PA, Payne S, Abel K, Beutler E, Ziegler MG, Schork NJ, O’Connor DT. Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension, 49:96-106, 2007.
Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components, J Biol Chem, 281:26391-9, 2006.
Hoekstra HI, Hirschmann RJ, Bundey RA, Insel PI, Crossland JP. A single amino acid mutation contributes to adaptive beach mouse color pattern, Science, 313:101-4, 2006.
Bundey RA, Insel PA. Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function, Mol Pharmacol, 70:1700-1707, 2006.
Akimova, OA, Grygorzcyk A, Bundey RA, Gekle M, Insel PA, Orlov SG. Transient activation and delayed inhibition of NA+, K+, Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms, J Biol Chem, 281:31317-25, 2006.
Swaney JS, Patel HH, Yokoyama U, Head BP, Roth DM, Insel PA. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin, J Biol Chem, 281:17173-9, 2006.
Arthur DB, Georgi S, Akassoglou K, Insel PA. Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival, J Neuroscience, 26:3798-804, 2006.
Patel HH, Head BP, Petersen HN, Niesman IR, Feramisco JR, Farquhar MG, Gross GJ, Insel PA, Roth DM. Protection of adult rat cardiomyocytes from ischemic cell death: role of caveolar microdomains and d-opioid receptors, Am J Physiol Heart Circ Physiol, 291:H344-50, 2006.
Buescher R, Hoerning A, Patel HH, Zhang S, Arthur, DB, Grasemann H, Ratjen F, Insel PA. P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx, Pharmacogenetics and Genomics, 16: 199-205, 2006.
Riddle EL, Rana BK, Murth KK, Rao F, Eskin E, O’Connor DT Insel PA. Polymorphisms and haplotypes of the regulator of G-protein signaling-2 gene in normotensives and hypertensives, Hypertension, 47:415-420, 2006.
Arthur DB, Akassoglou K, Insel PA. P2Y2 receptor activates NGF/TrkA receptor signaling to enhance neuronal differentiation, Proc Natl Acad Sci USA, 102:19138-19143, 2005.
Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and Lipid Rafts: G Protein-Coupled Receptor Signaling Microdomains in Cardiac Myocytes. Ann NY Acad Sci, 1047:166-172, 2005.
Akimova OA, Bouricer N, Taurin S, Bundey RA, Grygorczyk K, Geckle M, Insel PA, Dulin NO, Orlov SN. Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P2Y1 receptors, pohspohlipase A2 and protein kinase A. Am J Physiol, 568:789-801, 2005.
Insel PA, Head BP, Patel HH, Roth DM, Bundey RA, Swaney JS. Compartmentation of G-protein-coupled receptors and their signaling components in lipid rafts and caveolae. Biochem Soc Trans, 33:1131-4, 2005.
Zambon AC, Zhang L, Minovitsky S, Kanter J, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin B, Insel PA. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci USA, 102:8561-8566, 2005.
Etzel JP, Rana BK, Wen G, Parmer R, Schork N, O'Connor DT, Insel PA. Genetic variation at the human α2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension, 45:1207-13, 2005.
Publications -- Reviews
Insel PA, Patel HH. Membrane rafts and caveolae in cardiovascular signaling. Current Opinion in Nephrology and Hypertension. In press.
Patel HH, Murray F, Insel PA. G-protein-coupled receptor signaling components in membrane raft and caveolar microdomains. Handbook of Experimental Pharmacology, 186:167-84, 2008.
Patel HH, Murray F, Insel PA. Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol. 48:359-91, 2008.
Insel PA and Patel, HH. Do caveolin knock-outs teach us about physiology and pharmacology or instead, the ways mice compensate for “lost proteins”? Brit J Pharmacol, 150:251-4, 2007.
Insel PA, Tang CM, Hahntow I, Michel MC. Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets. Biochim Biophys Acta, 1768:994-1005, 2007.
Tang CM, Insel PA. Genetic variation in GPCRs – consequences for GPCRs as drug targets. Expert Opinion on Therapeutic Targets, 9:1247-65, 2005.
Insel PA, Head BP, Patel HH, Roth DM, Bundey RA, Swaney JS. Compartmentation of G-protein-coupled receptors and their signaling components in lipid rafts and caveolae. Biochem Soc Trans, 33:1131-34, 2005.
Ostrom RS and Insel PA. The evolving role of lipid rafts in G protein-coupled receptor signaling: Implications for molecular pharmacology. Brit J Pharmacol, 143:235-45, 2004.
Tang C-M, Insel PA. GPCR expression in the heart: "New" receptors in myocytes and fibroblasts. Trends Cardiovasc Med, 14:94-9, 2004.
Kirstein SL, Insel PA. Autonomic nervous system pharmacogenomics: a progress report.Pharmacological Reviews, 56:31-52, 2004.
Insel PA and Ostrom RS. Forskolin as a tool for examining adenylyl cyclase expression, regulation and G protein signaling. Cellular and Molecular Neurobiology, 23(3):305-314, 2003.
Ostrom RS, Post SR and Insel PA. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving Gs. J Pharmacol Exp Ther, 294(2):407-412, 2000.
