Computational Biology and Drug Design
Biochemical, cellular and molecular biological findings made by investigators
in the department are incorporated into and validated in animal models used
to understand human disease. A variety of transgenic, knock out and conditional
mutant mice have been developed by the faculty based on molecular and cellular
mechanisms discovered in their laboratories. These include animal models
of neurological, inflammatory and cardiovascular diseases including multiple
sclerosis, Alzheimer's disease, autism, Crone's disease, peripheral neuropathies
and neuropathic pain, hypertension, heart failure and cancer.
