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Laurence Brunton, Ph.D.

Professor of Pharmacology, Emeritus

Editor-in-Chief, Goodman & Gilman's The Pharmacological Basis of Therapeutics

Lawrence Brunton, Ph.D.

Laurence Brunton, Ph.D.
Recall Faculty, Pharmacology

Research Interests

I am an emeritus professor at the UCSD School of Medicine and an experienced researcher in cardiovascular physiology and pharmacology (cyclic nucleotide metabolism, subcellular compartmentation of signaling) and an experienced reviewer of research and training grants in the US and Mexico. I have served as an advisor to the CA Air Resources Board, as chair of the Biomedical Sciences Ph.D. Program, and as mentor for the Industry-UC Research Partnership Fellowship. I am the founding director of the UCSD Pharmacology Summer Undergraduate Research Fellowship program (to place under-represented students in research labs and recruit them to grad school), an NIH-funded research techniques course in physiology and pharmacology, and the San Diego IRACDA Program (Institutional Research and Academic Career Development Award, a NIGMS-funded postdoctoral program with a minority emphasis). Currently: My chief academic activity is as editor-in-chief of the major textbook in my field, Goodman and Gilman’s The Pharmacological Basis of Therapeutics, along with maintaining a webpage based on the book and preparing a student version, Goodman and Gilman’s Manual of Pharmacology and Therapeutics, and aiding development of the Goodman & Gilman Workbook and Casebook. I serve on the advisory boards for post-baccalaureate, Ph.D. and postdoctoral programs programs  and I am active in organizations that combat global warming and promote environmental health and economic justice.


Selected Publications

Cyclic nucleotide research -- still expanding after half a century. Nat Rev Mol Cell Biol. 2002 09; 3(9):710-8. Beavo JA, Brunton LL. PMID: 12209131.

Modeling beta-adrenergic control of cardiac myocyte contractility in silico. J Biol Chem. 2003 Nov 28; 278(48):47997-8003. Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. PMID: 12972422.

Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. J Biol Chem. 2003 Jul 04; 278(27):24461-8. Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG. PMID: 12711600.

Medical Student Attitudes toward Complementary, Alternative and Integrative Medicine. Evid Based Complement Alternat Med. 2011; 2011:985243. Abbott RB, Hui KK, Hays RD, Mandel J, Goldstein M, Winegarden B, Glaser D, Brunton L. PMID: 21826186; PMCID: PMC3147138.

Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K. Am J Physiol Cell Physiol. 2009 May; 296(5):C1178-84. Villarreal F, Epperson SA, Ramirez-Sanchez I, Yamazaki KG, Brunton LL. PMID: 19279233; PMCID: PMC2681376.

Brunton LL, Knollmann BC. Goodman and Gilman's The Pharmacological Basis of Therapeutics,14th Edition (editor -in - chief, LL Brunton), McGraw-Hill, New York, in press for publication in the fall of 2022. 



Cardiovascular & Metabolic Diseases
Immunology, Inflammation, & Infectious Diseases


Biochemical, Biophysical and Structural Pharmacology
Signaling & Molecular Pharmacology
Integrative Multi-Omics
Systems & Computational Biology


(858) 534-4667


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