Ryan Hibbs, Ph.D.
Professor and Vice-Chair of Neurobiology, Professor of Pharmacology
Ryan Hibbs, PhD
Professor and Vice Chair of Neurobiology, Professor of Pharmacology
Ryan Hibbs, Ph.D.
Professor and Vice Chair of Neurobiology
Professor of Pharmacology
Research Interests
We are investigating the fine details of fast communication in the nervous system, how this signaling goes awry in disease, and how drugs alter it. Ongoing projects span basic biophysics and structural biology to neuropharmacology, mechanisms underlying autoimmune diseases of the nervous system, and the evolution of neurotransmitter receptors.
Selected Publications
Li H, Teng J and Hibbs RE. "Structural switch in acetylcholine receptors in developing muscle." Nature 2024 July 31 online. PMID 39085615.
Chojnacka W, Teng J, Kim JJ, Jensen AA, Hibbs RE. "Structural insights into GABAA receptor potentiation by Quaalude." Nature Communications 2024 June 19. PMID 38898000.
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM#, Cecchini M#, Hibbs RE#. "Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation." Cell 2024 Feb 20. PMID: 38382524.
Allard CAH*, Kang G*, Kim JJ*, Valencia-Montoya WA, Hibbs RE# and Bellono NW#. “Structural basis of sensory receptor evolution in octopus."Nature 12 April 2023. PMID: 37045920.
Kang G*, Allard CAH*, Valencia-Montoya WA*, van Giesen L, Kim JJ, Bai X, Bellono NW# and Hibbs RE#. “Sensory specializations drive octopus and squid behavior.” Nature 12 April 2023. PMID: 37045917.
Noviello, C.M., Kreye, J., Teng, J., Pruss, H.# and Hibbs, R.E.# “Structural mechanisms of GABAA receptor autoimmune encephalitis.” Cell 2022 Jul 7;185(14):2469-2477.e13. PMID: 35803245
Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M. Jr., Lindahl, E., Hibbs, R.E. “Shared structural mechanisms of general anesthetics and benzodiazepines.” Nature 2020 585(7824):303-308. PMID: 32879488.