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Shigeki Miyamoto, DVM, Ph.D.
Adjunct Professor of Pharmacology

Research Interests

I completed my PhD research at the University of Tokyo, Japan in 1999 and was appointed as an assistant professor at Yamanashi-medical University (now Yamanashi University, School of Medicine). During my training and junior faculty position in Japan, I studied calcium mobilization-contractile regulation and ischemia/reperfusion-induced arrhythmias in the heart. In 2001, I was appointed as a postdoctoral fellow at UCSD, and became an Assistant Professor in 2009 and an Associate Professor of Pharmacology in 2015. I have devoted my research to elucidating mechanisms for cardiomyocyte death and survival. I found that Akt-induced phosphorylation of hexokinase-2 confers mitochondrial protection and that this process is negatively regulated by PHLPP1, an Akt phosphatase. I also demonstrated that hexokinase-2 regulates autophagy and mitophagy. I have also been interested in the mechanisms by which the small Gprotein RhoA regulates mitophagy and inflammation. I have also extended my research to understanding how the NLRP3 inflammasome activation contributes to adverse cardiac remodeling in response to stress. My overall goal is to elucidate the mechanisms by which these signaling molecules regulate cellular integrity against stress.


Selected Publications

Miyamoto S. Autophagy and cardiac aging. Cell Death & Differ. 2019. 26(4):653-664.

Suetomi T, Willeford A, Brand CS, Cho Y, Ross RS, Miyamoto S, Brown JH. Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. Circulation. 2018.138(22):2530-2544.

Tan VP, Smith JM, Tu M, Yu JD, Ding EY, Miyamoto S. Dissociation of mitochondrial HK-II elicits mitophagy and confers cardioprotection against ischemia. Cell death & disease. 2019. 10 (10):1-15.

Roberts DJ, Tan-Sah VP, Ding EY, Smith JM, Miyamoto S. Hexokinase-II Positively Reg- ulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition. Mol. Cell. 2014. 53(4):521-33.

Roberts DJ, Tan-Sah VP, Smith JM, Miyamoto S. Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes. J Biol Chem. 2013. 288(33):23798-806.

Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PHLPP-1 Negatively Regulates Akt Activity and Survival in the Heart. Circ Res. 2010.107(4):476-484.



Cancer Biology
Cardiovascular & Metabolic Diseases
Immunology, Inflammation, & Infectious Diseases
Neuropharmacology & Neurological Disorders


Signaling & Molecular Pharmacology


(858) 822-5696


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