Corina Antal, Ph.D.
Assistant Professor of Pharmacology
Corina Antal, Ph.D.
Assistant Professor of Pharmacology
Research Interests
Cancer arises from the concerted action of genetic mutations and epigenetic changes that lead to transcriptional alterations, ultimately impacting signal transduction. Our interests lie in investigating the interplay between epigenetics, RNA processing, and cell signaling to uncover new mechanisms underlying cancer progression. Our research goals are to identify novel epigenetic vulnerabilities in cancer and to elucidate mechanisms of posttranslational regulation of RNA-binding proteins that play a key role in tumorigenesis, in an effort to uncover new therapeutic approaches for cancer treatment. Dr. Antal’s laboratory uses a multidisciplinary approach to investigate the molecular underpinnings of pancreatic cancer progression, including epigenomics, high-throughput CRISPR and DNA base editing screens, computational approaches, and mouse models of pancreatic cancer.
Selected Publications
Antal CE, Oh TG, Aigner S, Luo E-C, Yee BA, Campos T, Tiriac H, Rothamel K, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banyo E, Bashi S, Esparza E, Munoz R, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DV, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. A super-enhancer regulated RNA-binding protein cascade drives pancreatic cancer. Nature Communications. 2023 Sep 6;14(1):5195. Epub 2023/09/07. doi: 10.1038/s41467-023-40798-6. PMID: 37673892. https://www.nature.com/articles/s41467-023-40798-6
Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015 Jan 29;160(3):489-502. doi: 10.1016/j.cell.2015.01.001. Epub 2015 Jan 22. PMID: 25619690; PMCID: PMC4313737.
Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Rep. 2015 Aug 25;12(8):1252-60. doi: 10.1016/j.celrep.2015.07.039. Epub 2015 Aug 13. PMID: 26279568; PMCID: PMC4551583
Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC. Intramolecular conformational changes optimize protein kinase C signaling. Chem Biol. 2014 Apr 24;21(4):459-469. doi: 10.1016/j.chembiol.2014.02.008. Epub 2014 Mar 13. PMID: 24631122; PMCID: PMC4020788.
Antal CE, Newton AC. Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics. 2013 Dec;12(12):3498-508. doi: 10.1074/mcp.R113.029819. Epub 2013 Jun 20. PMID: 23788531; PMCID: PMC3861703.
Antal CE, Newton AC. Tuning the signalling output of protein kinase C. Biochem Soc Trans. 2014 Dec;42(6):1477-83. doi: 10.1042/BST20140172. PMID: 25399557; PMCID: PMC5783555.