Michael Karin, Ph.D.
Distinguished Professor of Pharmacology and Pathology
Email: mkarin@health.ucsd.edu
Phone: 858-534-0872
Website:
Immunology, Inflammation, and Infectious Diseases
Immunity and Inflammation is a major determinant of human health and wellbeing whose importance has been underscored by the COVID 19 pandemic. The research in the Immunity and Inflammation Division is focused on understanding basic mechanisms of lymphocyte development and activation, control of innate and adaptive immunity and the major inflammation signaling pathways that result in NF-κB and inflammasome activation. The relevance of these basic mechanisms to human autoimmune and inflammatory diseases as well as tumor immunology and cancer immunotherapy is also being studied and our faculty members have made key contributions in all of these areas.
Immunity and Inflammation is a major determinant of human health and wellbeing whose importance has been underscored by the COVID 19 pandemic.
(A) Representative images from healthy (n=3) and COVID-19 post-mortem (n=11) tissue stained for CD68 (yellow) and ASC (red) taken at 20x. ASC specs mark inflammasome assembly. (B) hACE2 mice were infected with SARS CoV-2 without or with metformin treatment. Lung tissue was isolated, fixed and stained with ASC and F4/80 antibodies. Nuclei were counterstained with DAPI and images were captured by fluorescent confocal microscopy focusing on areas containing alveolar macrophages. Scale bar 7.5 μm. n = 4 mice per group. (C) Lung sections from above mice were stained with F4/80 and MPO antibodies. Scale bar 100 μm for F4/80 and MPO for highlighted areas. n=4 mice per group. 10-12 images per mouse were evaluated.
Division Director
Co-Director
Anjana Rao, Ph.D.
Professor of Signaling and Gene Expression Research
La Jolla Institute of Immunology
Email: arao@lji.org
Phone: 858-534-0872
Website:lji.org/labs/rao
The research in the Immunity and Inflammation Division is focused on understanding basic mechanisms of lymphocyte development and activation, control of innate and adaptive immunity and the major inflammation signaling pathways that result in NF-κB and inflammasome activation.
Division Faculty
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